3 edition of Phenothiazines and structurally related drugs found in the catalog.
Phenothiazines and structurally related drugs
International Symposium on Phenothiazines and Structurally Related Drugs (4th 1979 Zurich, Switzerland)
Includes bibliographical references and indexes.
|Statement||editors, Earl Usdin, Helmut Eckert, Irene S. Forrest.|
|Series||Developments in neuroscience ;, v. 7|
|Contributions||Usdin, Earl., Eckert, Helmut., Forrest, Irene S.|
|LC Classifications||RM666.P52 I57 1979|
|The Physical Object|
|Pagination||xx, 376 p. :|
|Number of Pages||376|
|LC Control Number||80011367|
phenothiazine (fē'nəthī`əzĭn), any one of a class of drugs used to control mental hiazines, along with other antipsychotic, or neuroleptic, drugs are used for such disorders as schizophrenia, paranoia, mania, psychosis resulting from mental deficiency, some forms of senility, hyperactivity in children, and even severe anxiety anxiety. dogenous substrates, as well as structurally dissimilar xenobiotics (including drugs) outside a cell . The Pgp overactivity reduces cell membrane permeability for various drugs, also for cytostatic drugs, and thereby decreases the effect of cancer chemotherapy . 18 Pharmacological Reports, , 64, 16 23 Tab. by:
Start studying Chapter phenothiazines and non-phenothiazines. Learn vocabulary, terms, and more with flashcards, games, and other study tools. phenothiazines: (fe?no-thi'a-zenz) A class of major tranquilizers used to treat psychotic illnesses such as schizophrenia. They have neuroleptic and antiemetic effects. Among the most commonly used agents in this class are chlorpromazine, haloperidol, prochlorperazine, and thioridazine. Side effects of these drugs include dystonic reactions.
Phenothiazine: One of a group of tranquilizing drugs with antipsychotic actions thought to act by blocking dopaminergic transmission (messages sent using the substance dopamine) within the brain. Examples of phenothiazines include: chlorpromazine (brand name: Thorazine), fluphenazine (Duraclon), mesoridazine (Serentil), perphenazine (Etrafon and . Phenothiazine, widely used anthelmintic (worming agent) in veterinary hiazine is an organic compound effective against a broad range of parasites in cattle, horses, poultry, sheep, and swine. A highly toxic drug, it is not recommended for human use and is not effective in dogs or cats.. Some of the most useful antipsychotic drugs are derivatives of phenothiazine.
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Phenothiazines and structurally related drugs; [proceedings]. of piperazine-substituted phenothiazine drugs / Ursula Breyer and Hans Jorg Gaertner --Binding behavior of phenothiazines and structurally related compounds to albumin from several # International Symposium on Phenothiazines and Structurally Related Drugs (3rd: Phenothiazines and Structurally Related Drugs; [Proceedings] (Advances in Biochemical Psychopharmacology) (v.
9): Medicine & Health Science Books @ Chlorpromazine is the prototype of phenothiazines, and is structurally related to promethazine, which is used as an antihistaminic.
Phenothiazines block the dopamine receptors in the basal ganglia, the hypothalamus, and the limbic system. Due to their effect on dopamine metabolism, they may cause extrapyramidal effects.
Phenothiazines and structurally related drugs: Basic and clinical studies: proceedings of the 4th International Symposium on Phenothiazines and(Developments in neuroscience) on *FREE* shipping on qualifying : Hardcover.
Get this from a library. Phenothiazines and structurally related drugs: basic and clinical studies: proceedings of the 4th International Symposium on Phenothiazines and Structurally Related Drugs, held in Zurich, Switzerland, September[Earl Usdin; Helmut Eckert; Irene S.
Phenothiazine antipsychotics are medications used to treat schizophrenia and manifestations of psychotic phenothiazine antipsychotics, like prochlorperazine and chlorpromazine, are used for nausea, vomiting, and hiccups.
Although, the exact mechanism of phenothiazine antipsychotics is unknown, scientists believe that they may work by blocking the. A set of 40 phenothiazines, thioxanthenes, and structurally related drugs with multidrug resistance modulating activity in tumor cells in vitro were selected from literature data and subjected to three-dimensional quantitative structure−activity relationship study using comparative molecular field analysis (CoMFA).
More than CoMFA models were derived and evaluated using steric Cited by: For personal accounts OR managers of institutional accounts. Username *.
Password *Author: J. Gillespie. Author(s): Eckert,Helmut; Forrest,Irene S; Usdin,Earl; International Symposium on Phenothiazines and Related Drugs,(4th: Zürich); International Symposium on Phenothiazines and Structurally Related Drugs,(3d: National Institute of Mental Health) Title(s): Phenothiazines and structurally related drugs: basic and clinical studies: proceedings.
Book reviewed in this article: Phenothiazines and Structurally Related Drugs. Advances in Biochemical Psycho‐pharmacology, Vol. Forrest, C. Carr, and E. Phenothiazine, abbreviated PTZ, is an organic compound that has the formula S(C 6 H 4) 2 NH and is related to the thiazine-class of heterocyclic tives of phenothiazine are highly bioactive and have widespread use and rich history.
The derivatives chlorpromazine and promethazine revolutionized the field of psychiatry and allergy treatment, ance: greenish-yellow rhombic leaflets or diamond-shaped plates. Phenothiazines and structurally related compounds alongside their other biological activities are able to modulate multidrug resistance (MDR) in tumor cells.
The extensive investigations on their MDR modulation effects consist part of the efforts to overcome MDR - the major obstacle in cancer by: Phenothiazines are used to treat serious mental and emotional disorders, including schizophrenia and other psychotic disorders.
Some are used also to control agitation in certain patients, severe nausea and vomiting, severe hiccups, and moderate to severe pain in some hospitalized patients. Chlorpromazine is used also in the treatment of. WARNING. Increased Mortality in Elderly Patients with Dementia-Related Psychosis. Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.
Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in. A comparative study of the thermodynamic properties at the air–water interface and in the bulk of structurally related phenothiazine drugs aqueous solutions.
Phenothiazines and structurally related compounds inhibit cellular proliferation and sensitize multidrug-resistant (MDR) cells to chemotherapeutic agents. To identify more potent pharmaceuticals, we studied the structure-activity relationships of 30 phenothiazines and related compounds on cellular proliferation and MDR in sensitive MCF-7 and resistant MCF-7/DOX Cited by: The phenothiazines are a group of chemical agents with neuroleptic, antiemetic, antihistaminic, anticholinergic and sedative activities.
Their main pharmacological response is determined by variations in the chemical structure of the side-chain at position 10 of the phenothiazine ring.
The most widely used antiemetics contain a basic amino group Cited by: Phenothiazines have their primary effects on the plasma membranes of prokaryotes and eukaryotes.
Among the components of the prokaryotic plasma membrane affected are efflux pumps, their energy sources and energy providing enzymes, such as ATPase, and genes that regulate and code for the permeability aspect of a bacterium.
The response of multidrug and Cited by: Phenothiazines reduce psychiatric disorders without causing addiction or euphoria; sedation usually only occurs in the early stages of drug therapy.
The most widely used phenothiazine, chlorpromazine chlorpromazine, one of a group of tranquilizing drugs called phenothiazines that are useful in halting psychotic episodes. In Phenothiazines and Structurally Related Drugs (ed. Forrest, C. Carr and E.
Usdin), Pergamon Press, New York, pp. –33 Google Scholar Craig, J. and Gruenke, L. Simultaneous determination of chlorpromazine and its major metabolites in plasma and red blood cells by a GC/MS method: clinical by:. phenothiazine (fē′nō-thī′ə-zēn′, -nə-) n.
1. A yellow organic compound, C12H9NS, used in insecticides, livestock anthelmintics, and dyes. 2. Any of a group of drugs derived from this compound and used in the treatment of psychiatric disorders, such as schizophrenia.
phenothiazine (ˌfiːnəʊˈθaɪəziːn) n 1. (Elements & Compounds.phenothiazines (fee-noh-th'y-ă-zeenz) pl. n. a group of chemically related compounds with various pharmacological actions. Some (e.g. chlorpromazine) are antipsychotic drugs; others (e.g. piperazine) are anthelmintics.Phenothiazine Drugs: Structure-Activity Relationships Explained by a tive potencies of several phenothiazine and related drugs as inhibitors ofthedopamine-sensitiveadenylate cyclase parallel phenothiazines assume a conformation that mimics that of dopamine, explaining the role of trifluoromethyl, piperazine, File Size: KB.